Signal Transduction
General Cell Signaling
- BioCarta:
Pathways - "Interactive graphic models of molecular and cellular
pathways."
- Biochemistry
Online: An Approach Based on Chemical Logic - Biochemistry within the
framework of chemical principles and logic. (Henry Jakubowski, College
of St. Benedict/St. John's University)
- Cell
Science at a Glance - "Signalling pathways, phylogenetic trees,
multiprotein complexes, useful reagents – and much more – summarized
in a single figure." (Journal of Cell Science)
- Cell
Signaling Pathway Slides and Charts (Sigma-Aldrich)
- NPG Web Focus: Kinases
in Cancer - "The Focus examines the role of kinase signalling in cancer
and the potential for developing effective therapies that can modulate various
kinase pathways." (Nature Publishing Group)
- Inositols.com - Resources covering
the following areas: inositols, phosphoinositides, phospholipids, lipid kinases,
cell signaling, inhibitors, calcium metabolism and other related topics.
(A.G. Scientific)
- The Interactive
Fly: Evolutionarily Conserved Pathways (Society for Developmental Biology).
Includes sections on:
- Kimball's
Biology Pages - A comprehensive online biology textbook. (Beginner's
Level)
- The Medical Biochemistry
Page - An excellent biochemistry tutorial with information on a broad
range of biochemical pathways. (Michael W. King, Indiana University School of Medicine)
- Regulators of Signal
Transduction Pathways - Information on transforming growth factor β (TGF-β),
Wnt, Janus kinase/signal transducer and activator of transcription (JAK/STAT),
Smad, adenomatous polyposis coli (APC)/β-catenin, lipid and other
signaling pathways.
- Signaling Gateway - Cell
signaling research, news, data and conferences. (Alliance for Cellular Signaling
and Nature Publishing Group)
- Signal Transduction Knowledge Environment -
Resources and information on signal transduction; an electronic journal with
perspectives and reviews. (Science and Stanford University)
- Wikipedia - Free online encyclopedia
with basic overviews. (Beginner's Level)
See also the Cell Cycle and Cytokinesis and Molecular
and Cell Biology of Development pages.
General Signal Transduction Databases
(Data Collections on Regulatory Pathways)
- Biological Biochemical Image Database -
Images of biological pathways, macromolecular structures, gene families and
cellular relationships. (National Institute of Aging)
- Database of Quantitative Cellular
Signaling - "The Database of Quantitative Cellular Signaling is
a repository of models of signaling pathways." (National Centre for
Biological Science, India)
- Dynamic Signaling Maps - "A
Web-based software suite that allows scientists and biomedical research organizations
to integrate, analyze, manipulate, and visualize biological signaling pathways
and protein-protein interaction data." (Hippron Physiomics)
- Kyoto Encyclopedia of Genes and Genomes
(KEGG) - Graphical and hypertext-based information on biochemical pathways,
including metabolic and regulatory pathways (for instance, cell cycle and
growth factor signaling).
- PhosphoSitePlus - A site "devoted to commonly studied protein post-translational modifications."
- The Signaling Pathway
Database (SPAD) - Database with diagrams of cell signaling pathways.
See also the Databases and
Simulations section of the Systems
Biology page. For specific signaling protein and pathway databases, see
below.
Signaling Ligands: Growth Factors, Cytokines, Trophic Factors, Hormones and
Neurotransmitters
- Cytokines Online Pathfinder
Encyclopaedia (COPE) - Extensive informational site on cytokines, chemokines
and receptors, with detailed descriptions of thousands of relevant proteins
and cell types. (Horst Ibelgaufts)
- The
Cytokines Web - Information about cytokines and their receptors that "provides
leading-edge scientific information about cytokines and their receptors,
including 3-D structural information and topological and evolutionary relationships.
It also contains information about potential theraputic uses for some human
cytokines."
- Neurotransmitter.net - This
is "a non-commercial project with an open-ended mission to educate and
innovate in the fields of neuroscience, psychology, and pharmacology."
- Neurotrophic
Factors - A collection of pages relating to the structures of neurotrophic
factors.
Receptors
- The G-Protein-Coupled Receptor Database
(GCRDb) - Database on G-protein-coupled receptors.
- The Glococoricoid Receptor
Resource - "The Glucocorticoid Receptor Resource is currently
a collection of facts on the GR, sources for clones and antibodies, maps/sequences
of GR expression vectors, and phenotypes of mutations." (Georgetown
University)
- The Nuclear Receptor
Resource - A collection of individual databases on members of the steroid
and thyroid hormone receptor superfamily (such as glucocorticoid, androgen,
thyroid hormone and mineralocorticoid receptors). (Georgetown University)
- NURSA - Nuclear Receptor Signaling
Atlas - "The primary directive of our NURSA program is to gather
and organize information relating to key aspects of orphan nuclear receptor
biology, with the aim of extending this blueprint to the wider discipline
of nuclear receptor signaling." (Co-Directors: Bert W. O'Malley, Baylor
College of Medicine; Ronald M. Evans, Salk Institute for Biological Studies)
- The Olfactory
Receptor Database (ORDB) - Database that "aims to house all of
the known olfactory receptor and chemoreceptor sequences in both nucleotide
and amino acid form." (Yale University)
Kinases
- Kinase.com - A "protein kinase gene resource.
This site contains analyses of protein kinases from humans and model organisms
(yeast, worm and fly), carried out by researchers at Sugen, Evolutionary
Bioinformatics, and the Salk Institute."
- Kinase Pathway
Database - An "integrated database concerning completed sequenced
major eukaryotes, which contains the classification of protein kinases
and their functional conservation and orthologous tables among species,
protein-protein interaction data, domain information, structural information,
and automatic pathway graph image interface."
- Kinase Substrate
Database - Database of published substrates for a broad range of kinases.
(Kinasource)
- The Protein Kinase Resource -
A compendium of information on protein kinases.
- Protein Kinase Resources -
General
resource with links to relevant recent literature, news and
job listings. (Ion Channel Media
Group)
Other Signaling Molecules
- The Calpain Family of Proteases -
Information on calpains, calcium-dependent cytosolic proteases involved in
signal transduction.
- Cyclic GMP Site - Resources
on the nitric oxide/cyclic GMP signaling pathway with diagrams, animations
and links.
- The EF-Hand Calcium-Binding
Proteins Data Library - "A growing collection of published sequence,
structural, functional, and other information about EF-hand calcium-binding
proteins and their roles in cellular signal transduction." (Melanie
Nelson, Physiome Sciences)
Specific Signaling Pathways
(Data
Collections on Metabolic Pathways)
Discussion Groups
See also the Discussion
Groups section of the General
Resources and Tutorials page.
Labs Studying